Bie Jia Jian Wan - 鳖甲煎丸

Invigorate the Blood and Qi, to eliminate accumulations of Blood stasis and Phlegm and soften and resolve hard masses.

Abdominal masses due to Qi, Blood and Phlegm stagnation.
Enlarged liver or spleen due to Qi, Blood and Phlegm stagnation

Bie Jia Jian Wan is traditionally indicated for malaria-like or Shaoyang symptoms, such as alternating chills and fever and diarrhoea or vomiting which do not resolve with treatment, and progress to the presence of hard masses or tumours, with possible emaciation, pain and jaundice. It is a warming and salty, stasis-melting formula.

Numerous studies have demonstrated the anti-cancer effects of Bie Jia Jian Wan, especially in regard to hepatocellular carcinoma (HCC). It has been shown to repress the proliferation, metastasis and infiltration of HCC cells, exert direct cytotoxic effects, and promote the beneficial infiltration of CD8+T cells into the tumour.

Sun J, Chen W, Wen B, Zhang M, Sun H, Yang X, Zhao W, La L, An H, Pang J, Gao L, He S. Biejiajian Pill Inhibits Carcinogenesis and Metastasis via the Akt/GSK-3β/Snail Signaling Pathway in Hepatocellular Carcinoma. Front Pharmacol. 2021 Mar 8;12:610158. doi: 10.3389/fphar.2021.610158. PMID: 33762939; PMCID: PMC7982731.

Yang X, Sun J, Wen B, Wang Y, Zhang M, Chen W, Zhao W, He C, Zhong X, Liu Y, Li T, Sun H, He S. Biejiajian Pill Promotes the Infiltration of CD8+ T Cells in Hepatocellular Carcinoma by Regulating the Expression of CCL5. Front Pharmacol. 2021 Nov 26;12:771046. doi: 10.3389/fphar.2021.771046. PMID: 34899325; PMCID: PMC8661106.

Jingjing H, Hongna H, Xiaojiao W, Yan G, Yuexue Z, Yueqiang H. Bie Jia Jian pill enhances the amelioration of bone mesenchymal stem cells on hepatocellular carcinoma progression. J Nat Med. 2022 Jan;76(1):49-58. doi: 10.1007/s11418-021-01548-4. Epub 2021 Jul 23. PMID: 34297271; PMCID: PMC8732910.


JGYL Chapter 4 Line 2: Question: Malaria that erupts on the first of each month should subside by the fifteenth day. If not, it should resolve by the end of the month. If the patient does not recover, what should we call this disease? The Master says: This means that the disease is binding into concretions or conglomerations. It is called mother of malaria. Treat this urgently. Bie Jia Jian Wan is appropriate.

Carapax Trionycis (Bie Jia)
Rhizoma Belamcanda (Wu Shan)
Radix Scutellariae (Huang Qin)
Radix Bupleuri (Chai Hu)
Armadillidium (Shu Fu)
Rhizoma Zingiberis (Gan Jiang)
Radix et Rhizoma Rhei (Da Huang)
Radix Paeoniae Rubra (Chi Shao)
Cortex Cinnamomi (Rou Gui)
Semen Lepidii (Ting Li ZI)
Folium Pyrrosiae (Shi Wei)
Cortex Magnoliae Officinalis (Hou Po)
Cortex Moutan (Mu Dan Pi)
Herba Dianthi (Qu Mai)
Folium Pyrrosiae (Ze Wei)
Rhizoma Pinelliae (Ban Xia)
Radix Ginseng (Ren Shen (Bai))
Eupolyphaga seu Steleophaga (Tu Bie Chong)
Colla Corii Asini (E Jiao)
Nidus Vespae (Feng Fang)
Nitrum Rubrum (Chi Xiao)
Catharsius (Qiang Lang)
Semen Persicae (Tao Ren)
Mel (Feng Mi)

* Contains Certified Organic Ingredients

Modern > Adults: Chew 3 honey pearls with warm water 3 times daily, or as otherwise directed by your health care professional.

Classical > Take seven pearls on an empty stomach, three times a day.

Supplement Facts
Each bottle contains: 50g / 1.76oz - Approx. 80 pearls
Paleo Friendly No artificial colours, flavours or preservatives, yeast, eggs, wheat, gluten, nuts, dairy.

• During pregnancy, always consult with a qualified healthcare practitioner before taking herbal medicines and nutritional supplements
• Always read the label. Use only as directed. If symptoms persist consult your healthcare practitioner.
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